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M94A2895.TXT
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1994-10-25
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Document 2895
DOCN M94A2895
TI Clinical evaluation of a HIV+ patient with Guillain-Barre syndrome
(GBS).
DT 9412
AU Watanabe R; Iino M; Tachikawa H; Honda M; Sagara H; Yokohama City
Hospital, Japan.
SO Int Conf AIDS. 1994 Aug 7-12;10(1):200 (abstract no. PB0227). Unique
Identifier : AIDSLINE ICA10/94369680
AB OBJECTIVE: a) To evaluate the clinical course and treatment of the first
Japanese HIV+ patient with GBS. b) To investigate the immunological
background of the patient. METHODS: Regular neurological examination was
carried out to assess both the clinical course and the effect of the
treatment, especially of AZT and steroid. Antibodies to the peripheral
nerve, Campylobacter Jejuni and a series of viruses were investigated.
RESULTS: The weakness, which was asymmetric including unilateral tongue
atrophy, progressed for more than one month and began to recede after 5
months. The clinical course was not influenced by treatment with steroid
or AZT. The antibody to Campylobacter Jejuni was negative. Pleocytosis
in CSF was observed, but it later reverted to normal. CONCLUSION: The
clinical picture of GBS with HIV infection was different from typical
GBS in terms of time course, weakness pattern and CSF findings.
Progression of the weakness was more protracted, but recovery was
observed even 8 months after onset. No definite neuroimmunological
background was disclosed.
DE Case Report Cerebrospinal Fluid/CYTOLOGY Human HIV
Infections/*COMPLICATIONS/DRUG THERAPY/IMMUNOLOGY
Polyradiculoneuritis/CEREBROSPINAL FLUID/*COMPLICATIONS/ IMMUNOLOGY
Steroids/THERAPEUTIC USE Zidovudine/THERAPEUTIC USE MEETING ABSTRACT
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).